Hongxin Wang Selected Research

astragaloside A

1/2021	Astragaloside IV attenuates inflammatory response mediated by NLRP-3/calpain-1 is involved in the development of pulmonary hypertension.
1/2020	Astragaloside IV prevents myocardial hypertrophy induced by mechanical stress by activating autophagy and reducing inflammation.
11/2019	Astragaloside IV alleviates myocardial damage induced by type 2 diabetes via improving energy metabolism.
9/2019	Astragaloside IV protects against hyperglycemia-induced vascular endothelial dysfunction by inhibiting oxidative stress and Calpain-1 activation.
1/2019	Astragaloside IV Suppresses High Glucose-Induced NLRP3 Inflammasome Activation by Inhibiting TLR4/NF-κB and CaSR.
1/2018	Calcium Sensing Receptor-Related Pathway Contributes to Cardiac Injury and the Mechanism of Astragaloside IV on Cardioprotection.
4/2017	Astragaloside IV inhibits isoprenaline‑induced cardiac fibrosis by targeting the reactive oxygen species/mitogen‑activated protein kinase signaling axis.
4/2016	Astragaloside IV improves the isoproterenol-induced vascular dysfunction via attenuating eNOS uncoupling-mediated oxidative stress and inhibiting ROS-NF-κB pathways.
11/2015	Astragaloside IV attenuates apoptosis of hypertrophic cardiomyocyte through inhibiting oxidative stress and calpain-1 activation.
4/2015	Astragaloside IV attenuates injury caused by myocardial ischemia/reperfusion in rats via regulation of toll-like receptor 4/nuclear factor-κB signaling pathway.

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Hongxin Wang Research Topics

Disease

13	Cardiomegaly (Heart Hypertrophy) 07/2019 - 01/2007
10	Inflammation (Inflammations) 01/2022 - 04/2014
9	Neoplasms (Cancer) 10/2022 - 12/2011
9	Hypertrophy 01/2020 - 01/2007
7	Body Weight (Weight, Body) 07/2019 - 01/2015
5	Cardiovascular Diseases (Cardiovascular Disease) 01/2019 - 01/2014
5	Atherosclerosis 01/2018 - 12/2014
4	Hepatocellular Carcinoma (Hepatoma) 10/2022 - 03/2016
4	Hypoxia (Hypoxemia) 01/2022 - 09/2013
3	Wounds and Injuries (Trauma) 03/2022 - 01/2017
3	Hypertension (High Blood Pressure) 01/2022 - 02/2016
3	Hyperglycemia 01/2020 - 09/2015
3	Fibrosis (Cirrhosis) 01/2020 - 04/2017
3	Reperfusion Injury 05/2015 - 04/2014
2	Carcinogenesis 10/2022 - 12/2011
2	Pulmonary Hypertension 01/2022 - 01/2021
2	Hemolysis 01/2022 - 12/2021
2	Stomach Ulcer (Gastric Ulcer) 06/2021 - 02/2018
2	Type 2 Diabetes Mellitus (MODY) 04/2021 - 11/2019
2	Infections 01/2019 - 03/2018
2	Dehydration (Water Stress) 03/2018 - 01/2017
2	Obesity 04/2016 - 02/2016
2	Glucose Intolerance 02/2016 - 12/2009
2	Heart Diseases (Heart Disease) 11/2015 - 07/2014
2	Brain Ischemia (Cerebral Ischemia) 01/2015 - 04/2014
2	Infarction (Infarctions) 04/2014 - 09/2013
2	Ischemia 09/2013 - 12/2008
1	Neoplasm Metastasis (Metastasis) 10/2022
1	Acne Vulgaris 06/2022
1	Dyslipidemias (Dyslipidemia) 01/2022
1	Spinal Cord Injuries (Spinal Cord Injury) 01/2022
1	Alopecia (Baldness) 01/2022
1	Neuromyelitis Optica (Devic's Disease) 01/2022
1	Right Ventricular Hypertrophy 01/2022

Drug/Important Bio-Agent (IBA)

13	Proteins (Proteins, Gene)FDA Link 10/2022 - 01/2007
12	astragaloside AIBA 01/2021 - 01/2014
8	Messenger RNA (mRNA)IBA 01/2020 - 01/2014
8	Isoproterenol (Isoprenaline)FDA LinkGeneric 09/2016 - 01/2007
7	Atrial Natriuretic Factor (ANF)IBA 01/2020 - 01/2014
6	CholesterolIBA 01/2022 - 12/2014
5	LipidsIBA 10/2021 - 11/2011
4	Cysteine Proteases (Cysteine Protease)IBA 01/2022 - 01/2015
4	Polysaccharides (Glycans)IBA 02/2018 - 07/2014
4	Opioid Receptors (Opioid Receptor)IBA 05/2015 - 12/2011
4	SaltsIBA 08/2012 - 01/2007
4	(trans)-Isomer 3,4- Dichloro- N- methyl- N- (2- (1- pyrrolidinyl)- cyclohexyl)- benzeneacetamideIBA 08/2012 - 01/2007
4	Leucine (L-Leucine)FDA Link 08/2012 - 01/2007
4	methanesulfonic acid (methanesulfonate)IBA 08/2012 - 01/2007
3	oxidized low density lipoproteinIBA 01/2022 - 01/2015
3	CalciumIBA 01/2022 - 07/2014
3	Reactive Oxygen Species (Oxygen Radicals)IBA 10/2021 - 04/2017
3	Glucose (Dextrose)FDA LinkGeneric 10/2021 - 11/2011
3	Simvastatin (Zocor)FDA LinkGeneric 02/2019 - 12/2016
3	CalcineurinIBA 01/2018 - 02/2012
3	Calcium-Calmodulin-Dependent Protein Kinase Type 2IBA 01/2018 - 07/2014
3	Apolipoproteins E (ApoE)IBA 01/2017 - 12/2014
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 10/2016 - 04/2014
3	kappa Opioid Receptors (kappa Opioid Receptor)IBA 02/2012 - 01/2007
3	Adrenergic Receptors (Adrenergic Receptor)IBA 02/2012 - 01/2007
2	HDL CholesterolIBA 01/2022 - 09/2015
2	Triglycerides (Triacylglycerol)IBA 01/2022 - 09/2015
2	ORALIT (ORS)IBA 01/2022 - 09/2013
2	Biological ProductsIBA 01/2022 - 03/2018
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2022 - 08/2017
2	Biomarkers (Surrogate Marker)IBA 10/2021 - 02/2015
2	Ethanol (Ethyl Alcohol)IBA 06/2021 - 02/2018
2	Insulin ReceptorIBA 04/2021 - 01/2015
2	CalpainIBA 01/2021 - 01/2018
2	AntioxidantsIBA 01/2020 - 09/2019
2	Streptozocin (Streptozotocin)FDA Link 07/2019 - 09/2015
2	Pharmaceutical PreparationsIBA 01/2019 - 04/2014
2	gingerolIBA 03/2018 - 01/2017
2	acetylleucyl-leucyl-norleucinalIBA 01/2018 - 01/2015
2	ApolipoproteinsIBA 01/2017 - 12/2014
2	NF-kappa B (NF-kB)IBA 10/2016 - 04/2014
2	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 05/2015 - 01/2015
2	Adenosine Triphosphate (ATP)IBA 05/2015 - 01/2015
2	Adenosine Monophosphate (AMP)IBA 05/2015 - 01/2015
2	norbinaltorphimineIBA 09/2013 - 02/2012
1	Glycoproteins (Glycoprotein)IBA 10/2022
1	Focal Adhesion Protein-Tyrosine KinasesIBA 10/2022
1	Hydroxy AcidsIBA 06/2022
1	AlginatesIBA 03/2022
1	PolylysineIBA 03/2022
1	PolymersIBA 03/2022
1	LDL CholesterolIBA 01/2022
1	Heavy MetalsIBA 01/2022
1	CobaltIBA 01/2022
1	NMDA receptor A1IBA 01/2022
1	Anaphylatoxin C5a ReceptorIBA 01/2022
1	Glutamic Acid (Glutamate)FDA Link 01/2022
1	Proliferating Cell Nuclear Antigen (PCNA)IBA 01/2022
1	Sirtuin 1IBA 01/2022
1	N-Methylaspartate (NMDA)IBA 01/2022
1	CollagenIBA 01/2022
1	Anti-Bacterial Agents (Antibiotics)IBA 12/2021
1	Ampicillin (Omnipen)FDA LinkGeneric 12/2021
1	Erythromycin (Erycette)FDA LinkGeneric 12/2021

Therapy/Procedure

4	Therapeutics 06/2022 - 01/2005
4	Oral Administration 06/2021 - 09/2015